EFFECT OF ETIOCHOLANOLONE ON GRANULOCYTE KINETICS

The effect of etiocholanolone on granulocyte kinetics in 12 hematologically normal patients was investigated using the technic of 3H-DFP [diisoflurophate] labeling of autologous blood in vitro. Baseline determinations of the total blood granulocyte pool (TBGP), the circulating pool (CGP), and the marginated pool (MGP) were performed. Following the administration of etiocholanolone, there was a 98% increase in the TBGP, which was considered to be due to mobilization of granulocytes from the bone marrow reserve. There was no change in the ratio of CGP to MGP. Etiocholanolone may be useful in the estimation of bone marrow reserve.