METAL-COMPLEXES OF BENZODIAZEPINES .3. SYNTHESIS AND CHARACTERIZATION OF ORGANOMETALLIC COMPLEXES OF PLATINUM(II)

被引：12

作者：

AVERSA, MC

BONACCORSI, P

CUSUMANO, M

GIANNETTO, P

MINNITI, D

机构：

[1] UNIV MESSINA,DIPARTIMENTO CHIM INORGAN & STRUTTURA MOLEC,I-98166 MESSINA,ITALY

[2] UNIV CAGLIARI,DIPARTIMENTO CHIM & TECNOL INORGAN & MET ORGAN,I-09124 CAGLIARI,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1991年 / 12期

关键词：

D O I：

10.1039/dt9910003431

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The complexes cis-[PtMe2(Me2SO)L1] and [PtR2L2] (R = Me or Ph) are easily obtained by reaction in CH2Cl2 of the complexes [PtMe2(Me2SO)2] or [{PtPh2(Et2S)}2] with L1 = 2,3-dihydro-2,2,4-trimethyl-1H-1,5-benzodiazepine or L2 = bromazepam = 7-bromo-1,3-dihydro-5-(2-pyridyl)2-H-1,4-benzodiazepin-2-one. They are the first examples of simple organometallic adducts of benzodiazepines with platinum(II). Their H-1 and C-13 NMR spectra suggest the co-ordination of L1 through N5, while L2 acts as a bidentate ligand by means of the imine and pyridine nitrogen atoms. The co-ordinated heterocyclic rings show a notable increase in their inversion barrier.

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页码：3431 / 3434

页数：4

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