DEVELOPMENTAL REGULATION OF CALMODULIN-DEPENDENT ADENYLATE-CYCLASE ACTIVITY IN AN INSECT ENDOCRINE GLAND

被引:27
作者
MELLER, V [1 ]
SAKURAI, S [1 ]
GILBERT, LI [1 ]
机构
[1] UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599
来源
CELL REGULATION | 1990年 / 1卷 / 10期
关键词
D O I
10.1091/mbc.1.10.771
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The insect prothoracic gland produces ecdysteroids that elicit molting and metamorphosis, and neurohormone stimulation of steroidogenesis by this gland involves both Ca2+ and cyclic adenosine monophosphate second messengers. Prothoracic gland adenylate cyclase exhibits a complex Ca2+/ calmodulin (CaM) dependence, a component of which requires an activated G8α for expression. A developmental switch in this system has been identified that correlates with a change in both regulation and function of the gland and involves the loss of sensitivity to extracellular Ca2+ at a time approximately concurrent with the loss of Ca2+/CaM sensitivity by the adenylate cyclase. The extent of cholera toxin activation of gland G8α is lowered before this developmental switch. However, no alterations in G8α levels or mobility are detected, suggesting that G8α interaction with another component in the signaling pathway, perhaps adenylate cyclase itself, produces the apparent Ca2+/CaM dependence and influences the ability of toxin to modify G8α. © 1990 by The American Society for Cell Biology.
引用
收藏
页码:771 / 780
页数:10
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