CELL-MEDIATED AND HUMORAL IMMUNE-RESPONSES INDUCED BY SCARIFICATION VACCINATION OF HUMAN VOLUNTEERS WITH A NEW LOT OF THE LIVE VACCINE STRAIN OF FRANCISELLA-TULARENSIS

被引：26

作者：

WAAG, DM

GALLOWAY, A

SANDSTROM, G

BOLT, CR

ENGLAND, MJ

NELSON, GO

WILLIAMS, JC

机构：

[1] USA, MED RES INST INFECT DIS, DIV MED, FREDERICK, MD 21702 USA

[2] USA, MED RES INST INFECT DIS, DIV BIOMETR & INFORMAT MANAGEMENT, FREDERICK, MD 21702 USA

[3] US FDA, CTR BIOL EVALUAT & RES, BETHESDA, MD 20892 USA

[4] NATL DEF RES ESTAB, DEPT MICROBIOL, S-90182 UMEA, SWEDEN

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1992年 / 30卷 / 09期

关键词：

D O I：

10.1128/JCM.30.9.2256-2264.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tularemia is a disease caused by the facultative intracellular bacterium Francisella tularensis. We evaluated a new lot of live F. tularensis vaccine for its immunogenicity in human volunteers. Scarification vaccination induced humoral and cell-mediated immune responses. Indications of a positive immune response after vaccination included an increase in specific antibody levels, which were measured by enzyme-linked immunosorbent and immunoblot assays, and the ability of peripheral blood lymphocytes to respond to whole F. tularensis bacteria as recall antigens. Vaccination caused a significant rise (P < 0.05) in immunoglobulin A (IgA), IgG, and IgM titers. Lymphocyte stimulation indices were significantly increased (P < 0.01) in vaccinees 14 days after vaccination. These data verify that this new lot of live F. tularensis vaccine is immunogenic.

引用

页码：2256 / 2264

页数：9

共 25 条

[1] AGGLUTININS AND ANTIBODIES TO FRANCISELLA-TULARENSIS OUTER-MEMBRANE ANTIGENS IN THE EARLY DIAGNOSIS OF DISEASE DURING AN OUTBREAK OF TULAREMIA [J].