CYCLIC 3',5'-AMP PHOSPHODIESTERASE IN PHYSARUM-POLYCEPHALUM .2. KINETIC-PROPERTIES

被引：11

作者：

KINCAID, RL ^{[1
]}

MANSOUR, TE ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PHARMACOL,STANFORD,CA 94305

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 588卷 / 03期

关键词：

(Physarum polycephalum); Chemotaxis; Cyclic AMP; Phosphodiesterase;

D O I：

10.1016/0304-4165(79)90342-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some kinetic characteristics of soluble and particulate cyclic 3′,5′-AMP phosphodiesterases from Physarum polycephalum are presented. The nature of enzyme inhibition by various agents is reported. The relationship between various enzyme inhibitors and their reported chemotactic properties in Physarum is examined. The results suggest that the chemoattractant effect of several inhibitors may be related to their ability to inhibit the particulate and extracellular phosphodiesterases, but is unrelated to inhibition of the intracellular enzyme. © 1979.

引用

页码：342 / 350

页数：9

共 24 条

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[6] MEASUREMENT OF CHEMOTAXIS IN SLIME-MOLD PHYSARUM-POLYCEPHALUM
KINCAID, RL
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[J]. EXPERIMENTAL CELL RESEARCH, 1978, 116 (02) : 365 - 375
[7] CHEMOTAXIS TOWARD CARBOHYDRATES AND AMINO-ACIDS IN PHYSARUM-POLYCEPHALUM
KINCAID, RL
MANSOUR, TE
[J]. EXPERIMENTAL CELL RESEARCH, 1978, 116 (02) : 377 - 385
[8] CYCLIC 3',5'-AMP PHOSPHODIESTERASE IN PHYSARUM-POLYCEPHALUM .1. CHEMOTAXIS TOWARD INHIBITORS AND CYCLIC-NUCLEOTIDES
KINCAID, RL
MANSOUR, TE
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 588 (03) : 332 - 341
[9] EFFECTS OF CYCLIC-AMP PULSES ON ADENYLATE-CYCLASE AND PHOSPHODIESTERASE INHIBITOR OF D-DISCOIDEUM
KLEIN, C
DARMON, M
[J]. NATURE, 1977, 268 (5615) : 76 - 78
[10] KLEIN C, 1975, BIOCHEM BIOPH RES CO, V67, P440, DOI 10.1016/0006-291X(75)90335-6

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