FOTEMUSTINE PLUS DACARBAZINE IN ADVANCED STAGE .3. MALIGNANT-MELANOMA

被引：11

作者：

BINDER, M ^{[1
]}

WINKLER, A ^{[1
]}

DORFFNER, R ^{[1
]}

GLEBOWSKI, E ^{[1
]}

WOLFF, K ^{[1
]}

PEHAMBERGER, H ^{[1
]}

机构：

[1] UNIV VIENNA,DEPT DERMATOL 1,ALSERSTR 4,A-1090 VIENNA,AUSTRIA

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 11期

关键词：

D O I：

10.1016/0959-8049(92)90010-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

19 patients with advanced malignant melanoma were treated with fotemustine and dacarbazine. Data recorded and available for evaluation in all patients included clinical and histopathological parameters of the primary melanoma, blood chemistry, blood cell count, chest X-ray, ultrasound and bone scan for initial staging of the site of metastases and follow-up during treatment. Dosage was fotemustine 100 mg/m2 and dacarbazine 200 mg/m2 intravenously twice monthly on days 1 and 8, repeated for a maximum of six courses. There were two complete and three partial responses in 5/19 patients (26%), and 8 patients (42%) had stable disease. 6 (32%) patients had no response. Median length of complete and partial responses was 3.9 months, and that of stable disease 4.2 months. The main side-effects were thrombocytopenia in 10 patients (53%) and nausea in 6 (32%); the nausea was easily suppressed by ondasetron. Thus, fotemustine-dacarbazine may be new treatment in advanced

引用

页码：1814 / 1816

页数：3

共 26 条

[1]

AAMDAL S, 1991, B CANCER PARIS, V78, P490

[2]

BLACH CM, 1985, CUTANEOUS MELANOMA C

[3]

BLACKWELL CP, 1989, EUR J CANCER CLIN ON, V25, pS21

[4]

BOAZIZ C, 1991, B CANCER, V78, P347

[5]

CARMOPEREIRA J, 1985, CANCER TREAT REP, V68, P1211

[6]

HILL GJ, 1984, CANCER, V53, P1299, DOI 10.1002/1097-0142(19840315)53:6<1299::AID-CNCR2820530613>3.0.CO

[7]

2-4

[8] CHEMOTHERAPY BY FOTEMUSTINE IN CEREBRAL METASTASES OF DISSEMINATED MALIGNANT-MELANOMA [J].

JACQUILLAT, C ;

KHAYAT, D ;

BANZET, P ;

WEIL, M ;

AVRIL, MF ;

FUMOLEAU, P ;

NAMER, M ;

BONNETERRE, J ;

KERBRAT, P ;

BONERANDI, JJ ;

BUGAT, R ;

MONTCUQUET, P ;

AUDHUY, B ;

CUPISSOL, D ;

LAUVIN, R ;

GROSSHANS, E ;

VILMER, C ;

PRACHE, C ;

BIZZARI, JP .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1990, 25 (04) :263-266

[9]

JACQUILLAT C, 1990, CANCER, V66, P1873, DOI 10.1002/1097-0142(19901101)66:9<1873::AID-CNCR2820660904>3.0.CO

[10]

2-5

← 1 2 3 →