THE EXPRESSION OF INTERSTITIAL COLLAGENASE IN HUMAN ENDOMETRIUM IS CONTROLLED BY PROGESTERONE AND BY ESTRADIOL AND IS RELATED TO MENSTRUATION

被引：96

作者：

MARBAIX, E

KOKORINE, I

HENRIET, P

DONNEZ, J

COURTOY, PJ

EECKHOUT, Y

机构：

[1] INT INST CELLULAR & MOLEC PATHOL, CONNECT TISSUE GRP, B-1200 BRUSSELS, BELGIUM

[2] INT INST CELLULAR & MOLEC PATHOL, CELL BIOL UNIT, B-1200 BRUSSELS, BELGIUM

[3] UNIV CATHOLIQUE LOUVAIN, SCH MED, CLIN UNIV ST LUC, DEPT PATHOL, B-1200 BRUSSELS, BELGIUM

[4] UNIV CATHOLIQUE LOUVAIN, SCH MED, CLIN UNIV ST LUC, DEPT GYNAECOL, B-1200 BRUSSELS, BELGIUM

来源：

BIOCHEMICAL JOURNAL | 1995年 / 305卷

关键词：

D O I：

10.1042/bj3051027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.

引用

页码：1027 / 1030

页数：4

共 17 条

[1] PROGESTERONE-RECEPTOR REGULATION IN UTERINE CELLS - STIMULATION BY ESTROGEN, CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE, AND INSULIN-LIKE GROWTH FACTOR-I AND SUPPRESSION BY ANTIESTROGENS AND PROTEIN-KINASE INHIBITORS [J].