GENERAL-CHARACTERISTICS OF OPTIMAL FEED RATE PROFILES FOR VARIOUS FED-BATCH FERMENTATION PROCESSES

被引：134

作者：

MODAK, JM ^{[1
]}

LIM, HC ^{[1
]}

TAYEB, YJ ^{[1
]}

机构：

[1] PURDUE UNIV,SCH CHEM ENGN,W LAFAYETTE,IN 47907

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1986年 / 28卷 / 09期

关键词：

BIOCHEMICAL ENGINEERING - Control Systems - CHEMICAL REACTIONS - Fermentation;

D O I：

10.1002/bit.260280914

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Optimal feed rate profiles for various fed-batch fermentation processes have been developed. Various fed-batch fermentation processes have been classified into three types, Types I-III, based on the form (nonmonotonicity) of the specific growth and product formation rates. The optimal feeding sequence is then proposed for each type based on a conjecture that in general the cells must be grown optimally first and then the product. As discussed in the text when the initial cell concentration is substantially high, the optimal policy may immediately favor the product formation rather than growing more cells.

引用

页码：1396 / 1407

页数：12

共 19 条

[1]

Bryson A.E, 1975, APPL OPTIMAL CONTROL

[2]

Fishman V M, 1974, Biotechnol Bioeng Symp, V0, P647

[3] OPTIMAL SUBSTRATE PROFILE FOR ANTIBIOTIC FERMENTATIONS [J].