STRUCTURE ELUCIDATION AND CHEMISTRY OF CATHARANTHUS ALKALOIDS .4. STRUCTURES OF HORHAMMERICINE AND HORHAMMERININE

被引：11

作者：

ABRAHAM, DJ

FARNSWOR.NR

LOUB, WD

BLOMSTER, RN

机构：

[1] Departments of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, University of Pittsburgh, Pittsburgh

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1969年 / 34卷 / 06期

关键词：

D O I：

10.1021/jo01258a009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several α-methyleneindoline bases have been reported isolated and characterized from Catharanthus, as well as from other species of plants. None of the monomeric α-methyleneindoline alkaloids from Catharanthus species have been shown to elicit antitumor activity; however, we have shown that lochnerinine exhibits significant cytotoxicity in cell culture against Eagle's 9 KB carcinoma of the nasopharynx.3. © 1969, American Chemical Society. All rights reserved.

引用

页码：1575 / &

共 10 条

[1] ABRAHAM DB, IN PRESS
[2] ISOLATION OF HORHAMMERICINE FROM C LANCEUS (APOCYNACEAE) ROOTS
BLOMSTER, RN
FARNSWORTH, NR
ABRAHAM, DJ
[J]. NATURWISSENSCHAFTEN, 1968, 55 (06) : 298 - +
[3] CATHARANTHUS ALKALOIDS .13. ANTINEOPLASTIC AND HYPOTENSIVE ACTIVITY OF ALKALOID FRACTIONS AND CERTAIN ALKALOIDS FROM CATHARANTHUS LANCEUS
FARNSWORTH, NR
BLOMSTER, RN
BUCKLEY, JP
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (01) : 23 - +
[4] FARNSWORTH NR, 1968, NATURFORSCH B, V23, P1061
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[6] MOZA BK, 1964, LLOYD, V27, P416
[7] NAIR CP, 1959, TETRAHEDRON LETT, P89
[8] PLAT M, 1962, B SOC CHIM FR, P2237
[9] PLAT M, 1962, ANN PHARM FR, V20, P899
[10] ALKALOIDS OF VINCA-ROSEA LINN (CATHARANTHUS-ROSEUS G-DON) .5. PREPARATION AND CHARACTERIZATION OF ALKALOIDS
SVOBODA, GH
NEUSS, N
GORMAN, M
[J]. JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1959, 48 (11): : 659 - 666

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