KINETICS OF BIOSYNTHESIS OF PHOSPHOLIPIDS IN NEURONS AND GLIAL CELLS ISOLATED FROM RAT BRAIN CORTEX

— 32P incorporation into different rat‐brain cortex neuronal and glial phospholipids was investigated. The half life of each compound was measured. Neuronal phospholipids had a faster turnover than glial phospholipids. Phosphatidyl‐inositol and choline plasmalogen had the fastest, diphosphatidylglycerol the lowest turnover in both cell‐types. Phosphatidylcholine, ethanolamine phospholipids and serine phospholipids had turnover intermediate with that of the previously described compounds. Turnover of neuronal sphingomyelin was similar to that of phosphatidylcholine, whereas in glial cells it was much lower. Copyright © 1969, Wiley Blackwell. All rights reserved