INSULIN RECEPTOR-BINDING IN OBESITY - REASSESSMENT

被引：39

作者：

MISBIN, RI

OLEARY, JP

PULKKINEN, A

机构：

来源：

SCIENCE | 1979年 / 205卷 / 4410期

关键词：

D O I：

10.1126/science.472718

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A defect in the binding of insulin to circulating monocytes occurs when obese patients are hospitalized and fed a liberal carbohydrate diet. Under ordinary circumstances, most obese patients have normal insulin binding despite very high concentrations of serum insulin. These results show that insulin does not necessarily regulate its own receptor in vivo-as it does in vitro.

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页码：1003 / 1004

页数：2

相关论文

共 15 条

[1] INSULIN RECEPTOR - ROLE IN RESISTANCE OF HUMAN OBESITY TO INSULIN [J].

AMATRUDA, JM ;

LIVINGSTON, JN ;

LOCKWOOD, DH .

SCIENCE, 1975, 188 (4185) :264-266

[2] DEFECT IN INSULIN BINDING TO RECEPTORS IN OBESE MAN - AMELIORATION WITH CALORIE RESTRICTION [J].

ARCHER, JA ;

GORDEN, P ;

ROTH, J .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 55 (01) :166-174

[3] INSULIN RECEPTORS IN PATIENTS WITH INSULINOMAS - CHANGES IN RECEPTOR AFFINITY AND CONCENTRATION [J].

BAR, RS ;

GORDEN, P ;

ROTH, J ;

SIEBERT, CW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 44 (06) :1210-1213

[4] FLUCTUATIONS IN AFFINITY AND CONCENTRATION OF INSULIN RECEPTORS ON CIRCULATING MONOCYTES OF OBESE PATIENTS - EFFECTS OF STARVATION, REFEEDING, AND DIETING [J].

BAR, RS ;

GORDEN, P ;

ROTH, J ;

KAHN, CR ;

DEMEYTS, P .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (05) :1123-1135

[5]

BAR RS, 1979, ADV INTERN MED, V23, P24

[6] DOWN REGULATION OF INSULIN RECEPTORS IN PRIMARY CULTURES OF ADULT RAT HEPATOCYTES IN MONOLAYER [J].

BLACKARD, WG ;

GUZELIAN, PS ;

SMALL, ME .

ENDOCRINOLOGY, 1978, 103 (02) :548-553

[7] INSULIN BINDING TO MONOCYTES AND INSULIN ACTION IN HUMAN OBESITY, STARVATION, AND REFEEDING [J].

DEFRONZO, RA ;

SOMAN, V ;

SHERWIN, RS ;

HENDLER, R ;

FELIG, P .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (01) :204-213

[8]

GAVIN JR, 1974, P NATL ACAD SCI USA, V71, P84, DOI 10.1073/pnas.71.1.84

[9] CORRELATION BETWEEN INSULIN RECEPTOR-BINDING IN ISOLATED FAT-CELLS AND INSULIN SENSITIVITY IN OBESE HUMAN SUBJECTS [J].

HARRISON, LC ;

MARTIN, FIR ;

MELICK, RA .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (06) :1435-1441

[10]

KOIVISTO V, 1979, CLIN RES, V27, pA487