CYTOGENETIC FINDINGS IN SECONDARY ACUTE NONLYMPHOCYTIC LEUKEMIA

被引：15

作者：

CARBONE, P ^{[1
]}

SANTORO, A ^{[1
]}

GIGLIO, MC ^{[1
]}

MIRTO, S ^{[1
]}

GRANATA, G ^{[1
]}

BARBATA, G ^{[1
]}

机构：

[1] OSPED V CERVELLO,DIV EMATOL,PALERMO,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 58卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90127-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We here report the results of cytogenetic studies carried out in eight patients with acute nonlymphocytic leukemia developed after primary neoplasias. In seven of the reported cases, clonal chromosome aberrations were found, some being specific of de novo acute nonlymphocytic leukemia (ANLL). Numerical abnormalities were detected, such as the total monosomy of chromosomes 5, 7, 21, trisomy of chromosomes 8, 11, 15, and duplication of chromosome Y. Structural changes were also observed: a del(12)(p12), a del(16)(q22), the translocations t(3;5)(p21;q35),t(3;7)(p21;q35), and t(12;14)(p12;q32) and other changes involving chromosome 8. The finding of a hypertetraploid karyotype with complex structural chromosome aberrations in a patient with erythroleukemia, developed after non-Hodgkin's lymphoma, is of particular interest. Data reported in this work are discussed with regard to the relationship between secondary and de novo ANLL and the finding of chromosome aberrations other than total or partial monosomy of chromosomes 5 and 7 is emphasized.

引用

页码：18 / 23

页数：6

共 41 条

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