LONG-TERM POTENTIATION OF EXCITATORY AND SLOW INHIBITORY SYNAPTIC POTENTIALS IN THE HIPPOCAMPAL-SEPTAL PROJECTION OF THE RAT

被引：22

作者：

STEVENS, DR ^{[1
]}

COTMAN, CW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717

来源：

BRAIN RESEARCH | 1991年 / 558卷 / 01期

基金：

美国国家卫生研究院;

关键词：

LONG-TERM POTENTIATION; N-METHYL-D-ASPARTATE; SEPTUM; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL;

D O I：

10.1016/0006-8993(91)90726-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hippocampal projection to the lateral septum was examined for use-dependent plasticity in a brain slice preparation using intracellular recording. Paired-pulse facilitation and posttetanic potentiation were present. Long-term potentiation (LTP) following high-frequency stimulation was observed after treatment with the GABA(A) antagonist bicuculline. A slow inhibitory synaptic potential also exhibited long-lasting potentiation after high-frequency stimulation. LTP of both components of the response was sensitive to NMDA antagonists.

引用

页码：120 / 122

页数：3

共 12 条

[1]

ANDERSEN P, 1966, EXP BRAIN RES, V1, P236

[2]

ANDERSON P, 1977, NATURE, V266, P737

[3] DIRECT AFFERENT EXCITATION AND LONG-TERM POTENTIATION OF HIPPOCAMPAL INTERNEURONS [J].