OXYGEN RADICALS AND THE CONTROL OF OVARIAN CORPUS-LUTEUM FUNCTION

The superoxide radical (SOR) and other reactive oxygen species form in cells during the course of respiration as well as in response to various stimuli. Although well known for their damaging effects, these agents can also work beneficially to control cell function. The present review examines the evidence that oxygen radicals and H2O2 may regulate steroid hormone biosynthesis in the ovarian corpus luteum. Recent findings indicate that luteal cells can employ reactive oxygen species at specific sites in controlling the production of progesterone over the course of the reproductive cycle and in inhibiting its synthesis during regression at the end of the cycle. These studies indicate that oxygen radicals and related compounds may function as intracellular regulators of steroidogenesis in the corpus luteum.