DIFFERENTIAL REGULATION OF PAIRED-PULSE PLASTICITY FOLLOWING LTP IN THE DENTATE GYRUS

被引:63
作者
CHRISTIE, BR [1 ]
ABRAHAM, WC [1 ]
机构
[1] UNIV OTAGO, NEUROSCI RES CTR, DUNEDIN, NEW ZEALAND
关键词
HIPPOCAMPUS; LTP; NMDA; PRESYNAPTIC; PERFORANT PATH; PAIRED-PULSE;
D O I
10.1097/00001756-199401120-00003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE mechanisms underlying the expression of long-term synaptic potentiation (LTP) in the lateral and medial perforant path inputs to the dentate gyrus were examined in pentobarbital anaesthetized rats. Lateral path LTP was accompanied by a robust, long-lasting reduction in lateral path paired-pulse facilitation (PPF). The reduction in PPF lasted for at least 1 h, and remained even after post-tetanic EPSP slopes were reduced to pre-tetanus levels. The induction of lateral path LTP and the corresponding reduction in PPF were blocked by the competitive NMDA receptor antagonist CPP. Medial path paired-pulse;depression was not affected by medial path LTP. These data suggest that changes in transmitter release may contribute more to lateral path than to medial path LTP.
引用
收藏
页码:385 / 388
页数:4
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