ETHICS, SCIENTIFIC VALIDITY, AND THE DESIGN OF EPIDEMIOLOGIC STUDIES

被引:21
作者
COUGHLIN, SS
BEAUCHAMP, TL
机构
[1] Department of Medicine, Divisions of Medical Oncology and Cardiology, Georgetown University School of Medicine, Washington, DC
[2] Kennedy Institute of Ethics, Georgetown University, Washington, DC
关键词
BIOETHICS; EPIDEMIOLOGIC METHODS; CASE-CONTROL STUDIES; VALIDITY; STUDY DESIGN; BIAS; GENDER; RACE; SOCIAL CLASS; PROXY RESPONDENTS;
D O I
10.1097/00001648-199207000-00009
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Ethical conflicts between moral principles and methodologic standards sometimes occur in epidemiologic research. When dilemmas are discerned, they may be analyzed using the ethical principles of beneficence, nonmaleficence, justice, and respect for the autonomy of persons. We argue that, in addition to scientific validity, the welfare and rights of research subjects should be taken into account in making decisions regarding all aspects of the design and conduct of epidemiologic studies, and that the commitment of epidemiologists to the advancement of scientific knowledge should not outweigh or override all other considerations.
引用
收藏
页码:343 / 347
页数:5
相关论文
共 35 条
[1]  
Susser M., Stein Z., Kline J., Ethics in epidemiology, Ann am Acad Polit Soc Sci, 437, pp. 128-141, (1978)
[2]  
Gordis L., Gold E., Seltser R., Privacy protection in epidemiologic and medical research: A challenge and a responsibility, Am J Epidemiol, 105, pp. 163-168, (1977)
[3]  
Waters W.E., Ethics and epidemiological research, Int J Epidemiol, 14, pp. 48-51, (1985)
[4]  
Altman D.G., Statistics and ethics in medical research: Study design, Br Med J, 281, pp. 1267-1269, (1980)
[5]  
Hennekens C.H., Buring JE. Epidemiology in Medicine, pp. 278-279, (1987)
[6]  
Schlesselman J.J., Case-Control Studies: Design, Conduct, Analysis, (1982)
[7]  
Rothman K.J., Modern Epidemiology. Boston, (1986)
[8]  
Strasser T., Jeanneret O., Raymond L., Ethical aspects of prevention trials, pp. 183-193, (1987)
[9]  
Rutstein D.D., The ethical design of human experiments, pp. 421-426, (1982)
[10]  
Altman D.G., Statistics and ethics in medical research: Misuse of statistics is unethical, Br Med J, 281, pp. 1182-1184, (1980)