PRESYNAPTIC INHIBITORY-ACTION OF A METABOTROPIC GLUTAMATE-RECEPTOR AGONIST ON EXCITATORY TRANSMISSION IN VISUAL CORTICAL-NEURONS

被引：55

作者：

SLADECZEK, F ^{[1
]}

MOMIYAMA, A ^{[1
]}

TAKAHASHI, T ^{[1
]}

机构：

[1] KYOTO UNIV, FAC MED, DEPT PHYSIOL, KYOTO 606, JAPAN

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1993年 / 253卷 / 1338期

关键词：

D O I：

10.1098/rspb.1993.0117

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A family of metabotropic glutamate receptors (mGluRs) has been elucidated by molecular cloning. To study the possible modulatory role of mGluRs in synaptic transmission, we tested the effect of a mGluR agonist, (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD), on the excitatory postsynaptic currents (EPSCS) recorded from neurons in thin slices of rat visual cortex, by using the whole-cell patch-clamp method. We found that trans-ACPD markedly suppressed the evoked EPSCS without affecting the mean amplitude of spontaneous miniature EPSCS. This effect on the evoked EPSCS was blocked by a potassium channel blocker, 4-aminopyridine (4-AP) in a dose-dependent manner We suggest that trans-ACPD presynaptically inhibits EPSCS by a mechanism involving the 4-AP-sensitive channels.

引用

页码：297 / 303

页数：7

共 40 条

[1] INTRACELLULAR CA2+ ACTIVATES A FAST VOLTAGE-SENSITIVE K+ CURRENT IN VERTEBRATE SYMPATHETIC NEURONS [J].