SYNTHESIS AND CHARACTERIZATION OF A SERIES OF HYDROPHOBIC ANTITUMOR BIS(CARBOXYLATO) (1,2-DIAMINOCYCLOHEXANE) PLATINUM(II) COMPLEXES

被引：15

作者：

ALBAKER, S ^{[1
]}

PEREZSOLER, R ^{[1
]}

KHOKHAR, AR ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BOX 52,1515 HOLCOMBE BLVD,HOUSTON,TX 77030

来源：

JOURNAL OF COORDINATION CHEMISTRY | 1993年 / 29卷 / 1-2期

关键词：

PLATINUM; 1,2-DIAMINOCYCLOHEXANE; CARBOXYLATE; LIPOSOMES; HYDROPHOBIC; SYNTHESIS;

D O I：

10.1080/00958979308037119

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of hydrophobic platinum(II) complexes of the type (DACH)PtX2 (where DACH = various isomeric forms of 1,2-diaminocyclohexane and X=pentanoato, hexanoato, heptanoato, octanoato, nonanoato, decanoato, unidecanoato, laurato, tridecanoato, myristato, pentadecanoato, palmitato, heptadecanoato, or stearato) has been synthesized and characterized using elemental analysis, infrared spectra and nuclear magnetic resonance (C-13{H-1} and Pt-195{H-1}). The complexes have been prepared as potential antitumor agents for liposome entrapment.

引用

页码：1 / 6

页数：6

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