PHENOTYPE ANALYSIS OF INFLAMMATORY MACROPHAGES IN RHEUMATOID-ARTHRITIS BY 2-COLOR CYTOFLUOROMETRY AND IMMUNOHISTOLOGY

被引：6

作者：

EMMRICH, F ^{[1
]}

GEBAUER, F ^{[1
]}

WESELOH, G ^{[1
]}

GLUCKERT, K ^{[1
]}

KINNE, R ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,DEPT ORTHOPED SURG,W-8520 ERLANGEN,GERMANY

来源：

AGENTS AND ACTIONS | 1990年 / 29卷 / 1-2期

关键词：

D O I：

10.1007/BF01964729

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several monocyte/macrophage surface antigens (CD13, MHC II, Ki-M8) were found to be overexpressed in various compartments i.e. peripheral blood, synovial fluid and inflamed synovial membrane of RA patients. A decreased expression of CD11a (LFA-1) on CD14+ cells could be observed in RA synovial membranes and in synovial fluid as compared to PMNC. This finding was confirmed by immunohistology. Synovial lining cells lacked CD11a, but expressed CD11b and c. Although speculative, one could imagine that a CD14+ subpopulation of macrophages expressing CD11a in the circulation either does not migrate to the lining layer or loses CD11a during migration and differentiation. © 1990 Birkhäuser Verlag.

引用

页码：95 / 97

页数：3

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