MORPHOLOGICAL AND FUNCTIONAL-STUDIES DURING AGING AT MITOCHONDRIAL LEVEL - ACTION OF DRUGS

被引：21

作者：

DELACRUZ, J ^{[1
]}

BURON, I ^{[1
]}

RONCERO, I ^{[1
]}

机构：

[1] UNIV CORDOBA,FAC CIENCIAS,DEPT BIOL CELULAR,CORDOBA,SPAIN

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 07期

关键词：

D O I：

10.1016/0020-711X(90)90008-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Mitochondria show morphological changes on aging: the volume density decreases and the total surface area or volume increase. 2. 2. Biochemical studies indicated a decrease in the rate of oxygen consumption and ATP levels for increasing age. Measurements of calcium transport across the mitochondrial membrane revealed a decrease in accumulated calcium and an alteration in the uptake kinetics of the ion in older animals. 3. 3. Theophylline and calcitonin action were also studied. In both age groups (young and old) theophylline shows an inhibitory effect on all the parameters studied (both morphological and biochemical). 4. 4. Calcitonin showed no effect on morphological and respiratory parameters, although it increased calcium uptake into the mitochondrion to a lesser extent in the 24 month old animals. © 1990.

引用

页码：729 / 735

页数：7

共 24 条

[1] THE PECULIARITIES OF PROTEIN AND RNA-SYNTHESES IN THE HEPATIC MITOCHONDRIA OF YOUNG AND OLD ANIMALS - STUDIES WITHOUT THE USE OF AN ANTIBIOTIC [J].

ADENUGA, GA ;

MAZAEV, AG ;

OLOWOOKERE, JO .

EXPERIMENTAL GERONTOLOGY, 1988, 23 (01) :35-41

[2] EFFECTS OF AGING ON RESPIRATION, ATP LEVELS AND CALCIUM-TRANSPORT IN RAT-LIVER MITOCHONDRIA - RESPONSE TO THEOPHYLLINE [J].

ALEMANY, J ;

DELACRUZ, MJ ;

RONCERO, I .

EXPERIMENTAL GERONTOLOGY, 1988, 23 (01) :25-34

[3] REGULATION OF CELLULAR CALCIUM-METABOLISM AND CALCIUM-TRANSPORT BY CALCITONIN [J].

BORLE, AB .

JOURNAL OF MEMBRANE BIOLOGY, 1975, 21 (1-2) :125-146

[4] INTRACELLULAR CALCIUM HOMEOSTASIS [J].

CARAFOLI, E .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :395-433

[5]

CARAFOLI E, 1979, MEMBRANE BIOCHEM, P41

[6] THE EFFECTS OF CALCITONIN ON CALCIUM-UPTAKE AND RESPIRATION IN RAT-LIVER MITOCHONDRIA [J].

DELACRUZ, MJ ;

ALEMANY, J ;

DECOS, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 852 (2-3) :169-174

[7] CHANGES INDUCED BY CAFFEINE, THEOPHYLLINE AND THEOBROMINE ON CALCIUM-UPTAKE, RESPIRATION AND ATP LEVELS IN RAT-LIVER MITOCHONDRIA [J].

DELACRUZ, MJ ;

ALEMANY, J ;

RONCERO, I ;

ALBERT, P .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1988, 91 (02) :443-447

[8] IS CELL AGING CAUSED BY RESPIRATION-DEPENDENT INJURY TO THE MITOCHONDRIAL GENOME [J].

FLEMING, JE ;

MIQUEL, J ;

COTTRELL, SF ;

YENGOYAN, LS ;

ECONOMOS, AC .

GERONTOLOGY, 1982, 28 (01) :44-53

[9]

FLEMING JE, 1984, NEWSLETT L PAULING I, V2, P1

[10] ION-CHANNEL COMPONENT OF CYTOCHROME-OXIDASE [J].

FRY, M ;

GREEN, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (06) :2664-2668

← 1 2 3 →