CATALEPSY INDUCED BY CARBACHOL MICROINJECTED INTO THE PONTINE RETICULAR-FORMATION OF RATS

被引：14

作者：

ELAZAR, Z

PAZ, M

机构：

[1] Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv

来源：

NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期

关键词：

Carbachol; Catalepsy; Pontine reticular formation; Rat;

D O I：

10.1016/0304-3940(90)90459-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats were implanted stereotaxically with permanent guide tubes aimed at the pontine reticular formation. Carbachol was microinjected in the awake, freely moving rats. Catalepsy was evaluated with the horizontal bar test. Intense and long-lasting, dose-dependent catalepsy was observed following microinjections of 2-8 μg of carbachol. Pretreatment with intrapeitoneally administered scopolamine significantly reduced the cataleptogenic effect of carbachol. These results show that the pontine reticular formation is part of the neuroanatomical substrate of catalepsy induced by cholinergic drugs. © 1990.

引用

页码：226 / 230

页数：5

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