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INTERLEUKIN-1 INDUCES RAPID AND TRANSIENT EXPRESSION OF THE C-FOS PROTOONCOGENE IN ISOLATED PANCREATIC-ISLETS AND IN PURIFIED BETA-CELLS

被引：33
作者：
HUGHES, JH
WATSON, MA
EASOM, RA
TURK, J
MCDANIEL, ML
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,BOX 8118,660 S EUCLID AVE,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DIV LAB MED,ST LOUIS,MO 63110
[3] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110
来源：
FEBS LETTERS | 1990年 / 266卷 / 1-2期
关键词：
c-fos; Insulin secretion; Interleukin; 1; Pancreatic islet; β-cell;
D O I：
10.1016/0014-5793(90)81499-E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of interleukin-1β (IL-1) on expression of c-fos mRNA in isolated rat pancreatic islets was examined. Accumulation of c-fos mRNA was demonstrable after 30 min of exposure to IL-1, peaked by 60 min, and declined thereafter. Fluorescence-activated cell sorting (FACS) of dispersed islet cells was employed to localize the accumulation of c-fos mRNA to the β-cell. Cycloheximide did not influence the induction of c-fos mRNA by IL-1. Accumulation of c-fos mRNA therefore appears to be an early signal transduction event in the β-cell and a component of the cellular mechanism(s) by which IL-1 influences β-cell function. © 1990.
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页码：33 / 36
页数：4
相关论文
共 32 条
[1]   CYTOTOXICITY OF HUMAN PI-7 INTERLEUKIN-1 FOR PANCREATIC-ISLETS OF LANGERHANS [J].
BENDTZEN, K ;
MANDRUPPOULSEN, T ;
NERUP, J ;
NIELSEN, JH ;
DINARELLO, CA ;
SVENSON, M .
SCIENCE, 1986, 232 (4757) :1545-1547
[2]   INTERLEUKIN-1 INDUCES C-FOS PROTOONCOGENE EXPRESSION IN CULTURED HUMAN-ENDOTHELIAL CELLS [J].
COLOTTA, F ;
LAMPUGNANI, MG ;
POLENTARUTTI, N ;
DEJANA, E ;
MANTOVANI, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (03) :1104-1110
[3]   INTERLEUKIN-1 IS POTENT MODULATOR OF INSULIN-SECRETION FROM ISOLATED RAT ISLETS OF LANGERHANS [J].
COMENS, PG ;
WOLF, BA ;
UNANUE, ER ;
LACY, PE ;
MCDANIEL, ML .
DIABETES, 1987, 36 (08) :963-970
[4]   MEMORIES OF FOS [J].
CURRAN, T ;
MORGAN, JI .
BIOESSAYS, 1987, 7 (06) :255-258
[5]   FOS AND JUN - THE AP-1 CONNECTION [J].
CURRAN, T ;
FRANZA, BR .
CELL, 1988, 55 (03) :395-397
[6]  
CURTIS BM, 1990, J IMMUNOL, V144, P1295
[7]  
EIZIRIK DL, 1989, DIABETOLOGIA, V32, P769
[8]   DIFFERENTIAL SENSITIVITY TO BETA-CELL SECRETAGOGUES IN CULTURED RAT PANCREATIC-ISLETS EXPOSED TO HUMAN INTERLEUKIN-1-BETA [J].
EIZIRIK, DL ;
SANDLER, S ;
HALLBERG, A ;
BENDTZEN, K ;
SENER, A ;
MALAISSE, WJ .
ENDOCRINOLOGY, 1989, 125 (02) :752-759
[9]   INSULIN-SECRETING BETA-CELLS POSSESS SPECIFIC RECEPTORS FOR INTERLEUKIN-1-BETA [J].
HAMMONDS, P ;
BEGGS, M ;
BERESFORD, G ;
ESPINAL, J ;
CLARKE, J ;
MERTZ, RJ .
FEBS LETTERS, 1990, 261 (01) :97-100
[10]   INTERLEUKIN-1 INDUCES NEW PROTEIN-FORMATION IN ISOLATED RAT ISLETS OF LANGERHANS [J].
HELQVIST, S ;
HANSEN, BS ;
JOHANNESEN, J ;
ANDERSEN, HU ;
NIELSEN, JH ;
NERUP, J .
ACTA ENDOCRINOLOGICA, 1989, 121 (01) :136-140
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