MiniReview: Antiviral Targets Series, Number 1 Targets for antiviral chemotherapy: HIV-proteinase

被引:34
作者
Dunn, B. M. [1 ]
Kay, J. [2 ]
机构
[1] Univ Florida, J Hillis Miller Hlth Ctr, Dept Biochem & Mol Biol, Gainesville, FL 32610 USA
[2] Univ Wales Coll Cardiff, Dept Biochem, POB 903, Cardiff CF1 1ST, S Glam, Wales
基金
英国医学研究理事会;
关键词
D O I
10.1177/095632029000100102
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:3 / 8
页数:6
相关论文
共 18 条
[1]   SYNTHETIC NON-PEPTIDE INHIBITORS OF HIV PROTEASE [J].
BLUMENSTEIN, JJ ;
COPELAND, TD ;
OROSZLAN, S ;
MICHEJDA, CJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) :980-987
[2]   X-RAY STUDIES OF ASPARTIC PROTEINASE STATINE INHIBITOR COMPLEXES [J].
COOPER, JB ;
FOUNDLING, SI ;
BLUNDELL, TL ;
BOGER, J ;
JUPP, RA ;
KAY, J .
BIOCHEMISTRY, 1989, 28 (21) :8596-8603
[3]   THE SELECTIVITY OF STATINE-BASED INHIBITORS AGAINST VARIOUS HUMAN ASPARTIC PROTEINASES [J].
JUPP, RA ;
DUNN, BM ;
JACOBS, JW ;
VLASUK, G ;
ARCURI, KE ;
VEBER, DF ;
PERLOW, DS ;
PAYNE, LS ;
BOGER, J ;
DELASZLO, S ;
CHAKRAVARTY, PK ;
TENBROEKE, J ;
HANGAUER, DG ;
ONDEYKA, D ;
GREENLEE, WJ ;
KAY, J .
BIOCHEMICAL JOURNAL, 1990, 265 (03) :871-878
[4]   VIRAL PROTEINASES - WEAKNESS IN STRENGTH [J].
KAY, J ;
DUNN, BM .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1048 (01) :1-18
[5]   ACTIVITY OF PURIFIED BIOSYNTHETIC PROTEINASE OF HUMAN IMMUNODEFICIENCY VIRUS ON NATURAL SUBSTRATES AND SYNTHETIC PEPTIDES [J].
KRAUSSLICH, HG ;
INGRAHAM, RH ;
SKOOG, MT ;
WIMMER, E ;
PALLAI, PV ;
CARTER, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (03) :807-811
[6]   X-RAY-ANALYSIS OF HIV-1 PROTEINASE AT 2.7 A RESOLUTION CONFIRMS STRUCTURAL HOMOLOGY AMONG RETROVIRAL ENZYMES [J].
LAPATTO, R ;
BLUNDELL, T ;
HEMMINGS, A ;
OVERINGTON, J ;
WILDERSPIN, A ;
WOOD, S ;
MERSON, JR ;
WHITTLE, PJ ;
DANLEY, DE ;
GEOGHEGAN, KF ;
HAWRYLIK, SJ ;
LEE, SE ;
SCHELD, KG ;
HOBART, PM .
NATURE, 1989, 342 (6247) :299-302
[7]   SUBSTITUTION MUTATIONS OF THE HIGHLY CONSERVED ARGININE-87 OF HIV-1 PROTEASE RESULT IN LOSS OF PROTEOLYTIC ACTIVITY [J].
LOUIS, JM ;
SMITH, CAD ;
WONDRAK, EM ;
MORA, PT ;
OROSZLAN, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (01) :30-38
[8]   STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A SUBSTRATE-BASED INHIBITOR AT 2.3-A RESOLUTION [J].
MILLER, M ;
SCHNEIDER, J ;
SATHYANARAYANA, BK ;
TOTH, MV ;
MARSHALL, GR ;
CLAWSON, L ;
SELK, L ;
KENT, SBH ;
WLODAWER, A .
SCIENCE, 1989, 246 (4934) :1149-1152
[9]   CRYSTAL-STRUCTURE OF A RETROVIRAL PROTEASE PROVES RELATIONSHIP TO ASPARTIC PROTEASE FAMILY [J].
MILLER, M ;
JASKOLSKI, M ;
RAO, JKM ;
LEIS, J ;
WLODAWER, A .
NATURE, 1989, 337 (6207) :576-579
[10]   PEPTIDE-SUBSTRATES AND INHIBITORS OF THE HIV-1 PROTEASE [J].
MOORE, ML ;
BRYAN, WM ;
FAKHOURY, SA ;
MAGAARD, VW ;
HUFFMAN, WF ;
DAYTON, BD ;
MEEK, TD ;
HYLAND, L ;
DREYER, GB ;
METCALF, BW ;
STRICKLER, JE ;
GORNIAK, JG ;
DEBOUCK, C .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 159 (02) :420-425