INVITRO HEXOSAMINE DEPLETION OF INTACT ARTICULAR-CARTILAGE BY PROSTAGLANDINS-E - PREVENTION BY CHLOROQUINE

被引：36

作者：

FULKERSON, JP ^{[1
]}

LADENBAUERBELLIS, IM ^{[1
]}

CHRISMAN, OD ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, ORTHOPAED SURG SECT, NEW HAVEN, CT 06520 USA

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 10期

关键词：

D O I：

10.1002/art.1780221011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Short‐term incubations of intact canine articular cartilage slices with prostaglandins E1 and E2 caused significant losses of hexosamine from cartilage matrix compared to controls. Chloroquine, an inhibitor of DNA primer, prevented this prostaglandin‐induced hexosamine depletion. These data suggest that E‐prostaglandins may degrade articular cartilage directly through DNA‐dependent RNA synthesis of cathepsinlike proteases. Catabolism of articular cartilage probably involves degradation of existing matrix in addition to inhibition of synthesis. Copyright © 1979 American College of Rheumatology

引用

页码：1117 / 1121

页数：5

共 22 条

[1] STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS .6. THE PHYSIOLOGICAL DISPOSITION, ANTIMALARIAL ACTIVITY, AND TOXICITY OF SEVERAL DERIVATIVES OF 4-AMINOQUINOLINE [J].

BERLINER, RW ;

EARLE, DP ;

TAGGART, JV ;

ZUBROD, CG ;

WELCH, WJ ;

CONAN, NJ ;

BAUMAN, E ;

SCUDDER, ST ;

SHANNON, JA .

JOURNAL OF CLINICAL INVESTIGATION, 1948, 27 (03) :98-107

[2]

BOAS NF, 1953, J BIOL CHEM, V204, P553

[3] CHANGES IN LIPIDS OF HUMAN ARTICULAR-CARTILAGE WITH AGE [J].

BONNER, WM ;

JONSSON, H ;

MALANOS, C ;

BRYANT, M .

ARTHRITIS AND RHEUMATISM, 1975, 18 (05) :461-473

[4]

BUTCHER RW, 1968, J BIOL CHEM, V243, P1713

[5] INHIBITION OF DNA AND RNA POLYMERASE REACTIONS BY CHLOROQUINE [J].

COHEN, SN ;

YIELDING, KL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (02) :521-+

[6]

EHRLICH MG, 1975, J BONE JOINT SURG AM, VA 57, P570

[7] COLLAGENASES .3. [J].

HARRIS, ED ;

KRANE, SM .

NEW ENGLAND JOURNAL OF MEDICINE, 1974, 291 (13) :652-661

[8]

HIGGS GA, 1974, PROSTAGLANDIN SYNTHE, P165

[9] DEGRADATIVE ENZYMES IN OSTEOARTHRITIC HUMAN ARTICULAR-CARTILAGE [J].

HOWELL, DS .

ARTHRITIS AND RHEUMATISM, 1975, 18 (02) :167-177

[10] IMMUNOHISTOCHEMICAL LOCALIZATION OF PROSTAGLANDIN-E IN RHEUMATOID SYNOVIAL TISSUES [J].

HUSBY, G ;

BANKHURST, AD ;

WILLIAMS, RC .

ARTHRITIS AND RHEUMATISM, 1977, 20 (03) :785-791

← 1 2 3 →