CA2+ CALMODULIN-DEPENDENT PROTEIN KINASE-II IMMUNOREACTIVITY IN LEWY BODIES

被引：31

作者：

IWATSUBO, T ^{[1
]}

NAKANO, I ^{[1
]}

FUKUNAGA, K ^{[1
]}

MIYAMOTO, E ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT PHARMACOL,KUMAMOTO 860,JAPAN

来源：

ACTA NEUROPATHOLOGICA | 1991年 / 82卷 / 03期

关键词：

LEWY BODY; LEWY BODY-LIKE HYALINE INCLUSION; CA2+ CALMODULIN-DEPENDENT PROTEIN KINASE-II; PARKINSONS DISEASE; AMYOTROPHIC LATERAL SCLEROSIS;

D O I：

10.1007/BF00294440

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is one of the predominant protein kinases in the brain. We found that CaM kinase II immunoreactivity was concentrated in the peripheral halos of Lewy bodies (LBs) in Parkinson's disease and Lewy body-like hyaline inclusions (LBHIs) in amyotrophic lateral sclerosis. An immunoelectron microscopic examination of LBs revealed that the filaments at the periphery of LBs were decorated with immunopositive deposits. Since CaM kinase II has a broad substrate specificity and can phosphorylate neurofilaments and other cytoskeletal proteins, it may play some role in the formation of LBs and LBHIs through the aberrant phosphorylation of the cytoskeletal elements in these inclusions.

引用

页码：159 / 163

页数：5

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