3 NONPHENOLIC DIARYLHEPTANOIDS WITH ANTIINFLAMMATORY ACTIVITY FROM CURCUMA-XANTHORRHIZA

被引：62

作者：

CLAESON, P

PANTHONG, A

TUCHINDA, P

REUTRAKUL, V

KANJANAPOTHI, D

TAYLOR, WC

SANTISUK, T

机构：

[1] MAHIDOL UNIV,FAC SCI,DEPT CHEM,RAMA VI RD,BANGKOK 10400,THAILAND

[2] CHIANG MAI UNIV,FAC MED,DEPT PHARMACOL,CHIANG MAI 50002,THAILAND

[3] UNIV SYDNEY,DEPT ORGAN CHEM,SYDNEY,NSW 2006,AUSTRALIA

[4] ROYAL FORESTRY DEPT,FOREST HERBARIUM,BANGKOK 10900,THAILAND

来源：

PLANTA MEDICA | 1993年 / 59卷 / 05期

关键词：

CURCUMA-XANTHORRHIZA; ZINGIBERACEAE; MEDICINAL PLANT; DIARYLHEPTANOIDS; NMR; ANTIINFLAMMATORY ACTIVITY;

D O I：

10.1055/s-2006-959730

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of a hexane extract of the rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) led to the isolation of three non-phenolic diarylheptanoids, identified mainly by high-field H-1-NMR as trans-trans-1,7-diphenyl-1,3-heptadien-4-one (alnustone), trans-1,7-diphenyl-1-hepten-5-ol, and trans,trans-1,7-diphenyl-1,3-heptadien-5-ol. The latter is reported for the first time as a plant constituent. Germacrone, curzerenone, and cinnamaldehyde were also isolated and identified. The three diarylheptanoids all exerted significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.

引用

页码：451 / 454

页数：4

共 14 条

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