USE OF LIPOSOME PREPARATION TO TREAT MYCOBACTERIAL INFECTIONS

被引:25
作者
BERMUDEZ, LE
机构
[1] Kuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco, Pacific Presbyterian Medical Center, San Francisco, California
关键词
D O I
10.1016/S0171-2985(11)80465-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infections caused by organisms of the genus mycobacteria, such as tuberculosis M. avium disseminated infection in AIDS patients and leprosy, are extremely common around the world. Mycobacteria are intracellular organisms that invade and multiply chiefly within phagocytic cells. Antibiotic resistance among mycobacteria is a growing concern. M. tuberculosis resistant to INH and rifampin are increasing in major urban centers of the developed and in the developing world. M. avium is characteristically resistant to most anti-tuberculosis antibiotics. Furthermore, therapy of mycobacterial infections rakes a long time and most of the drugs have potential side effects and toxicity. In addition, mycobacteria is found within cells and antimicrobials need to be able to achieve adequate concentration within the compartment where mycobacteria is located. Liposome preparations, containing antibiotics, have a theoretical advantage in being able to deliver high concentrations of antimicrobials into the infected cell. Studies done thus far, in vitro and in vivo, have confirmed this premise, when comparing drug entrapped in liposomes with free drug. This paper summarizes the results obtained using liposome preparations to treat mycobacterial infections.
引用
收藏
页码:578 / 583
页数:6
相关论文
共 17 条
[1]   TREATMENT OF DISSEMINATED MYCOBACTERIUM-AVIUM COMPLEX INFECTION OF BEIGE MICE WITH LIPOSOME-ENCAPSULATED AMINOGLYCOSIDES [J].
BERMUDEZ, LE ;
YAUYOUNG, AO ;
LIN, JP ;
COGGER, J ;
YOUNG, LS .
JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (06) :1262-1268
[2]   STIMULATION WITH CYTOKINES ENHANCES PENETRATION OF AZITHROMYCIN INTO HUMAN MACROPHAGES [J].
BERMUDEZ, LE ;
INDERLIED, C ;
YOUNG, LS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (12) :2625-2629
[3]   TUBERCULOSIS - COMMENTARY ON A REEMERGENT KILLER [J].
BLOOM, BR ;
MURRAY, CJL .
SCIENCE, 1992, 257 (5073) :1055-1064
[4]   COMPARISON OF 15 LABORATORY AND PATIENT-DERIVED STRAINS OF MYCOBACTERIUM-AVIUM FOR ABILITY TO INFECT AND MULTIPLY IN CULTURED HUMAN MACROPHAGES [J].
CROWLE, AJ ;
TSANG, AY ;
VATTER, AE ;
MAY, MH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 24 (05) :812-821
[5]   EVIDENCE THAT VESICLES CONTAINING LIVING, VIRULENT MYCOBACTERIUM-TUBERCULOSIS OR MYCOBACTERIUM-AVIUM IN CULTURED HUMAN MACROPHAGES ARE NOT ACIDIC [J].
CROWLE, AJ ;
DAHL, R ;
ROSS, E ;
MAY, MH .
INFECTION AND IMMUNITY, 1991, 59 (05) :1823-1831
[6]   ACTIVITY OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME - A CONTROLLED CLINICAL-TRIAL [J].
DAUTZENBERG, B ;
TRUFFOT, C ;
LEGRIS, S ;
MEYOHAS, MC ;
BERLIE, HC ;
MERCAT, A ;
CHEVRET, S ;
GROSSET, J .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (03) :564-569
[7]   ENHANCED EFFECT OF LIPOSOME-ENCAPSULATED AMIKACIN ON MYCOBACTERIUM-AVIUM-M INTRACELLULARE COMPLEX INFECTION IN BEIGE MICE [J].
DUZGUNES, N ;
PERUMAL, VK ;
KESAVALU, L ;
GOLDSTEIN, JA ;
DEBS, RJ ;
GANGADHARAM, PRJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) :1404-1411
[8]   INVITRO AND INVIVO ACTIVITIES OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM [J].
FERNANDES, PB ;
HARDY, DJ ;
MCDANIEL, D ;
HANSON, CW ;
SWANSON, RN .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) :1531-1534
[9]   INVITRO AND INVIVO ACTIVITY OF AZITHROMYCIN (CP-62,993) AGAINST THE MYCOBACTERIUM-AVIUM COMPLEX [J].
INDERLIED, CB ;
KOLONOSKI, PT ;
WU, M ;
YOUNG, LS .
JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (05) :994-997
[10]   EFFICACIES OF LIPOSOME-ENCAPSULATED STREPTOMYCIN AND CIPROFLOXACIN AGAINST MYCOBACTERIUM-AVIUM-M-INTRACELLULARE COMPLEX INFECTIONS IN HUMAN PERIPHERAL-BLOOD MONOCYTE MACROPHAGES [J].
MAJUMDAR, S ;
FLASHER, D ;
FRIEND, DS ;
NASSOS, P ;
YAJKO, D ;
HADLEY, WK ;
DUZGUNES, N .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) :2808-2815