GASTRO-INTESTINAL TUMOURS IN RATS AND MICE FOLLOWING VARIOUS ROUTES OF ADMINISTRATION OF N-METHYL-N-NITROSO-N'-NITROGUANIDINE AND N-ETHYL-N-NITROSO-N'-NITROGUANIDINE

Alkylnitrosoguanidines, the methyl and the ethyl homologues induce in rats mainly tumours of the stomach, when given intragastrically, and tumours of the intestines when injected intraperitoneally. Mice are also susceptible to these compounds, which, like the respective alkylnitrosourethanes, yield an alkylating entity on interacting with sulphydryls, without the need of enzymic activation. We thank Mr. R. F. Legg for the microphotographs and Mrs Nina Marks for valuable technical assistance. © 1969, The British Empire Cancer Campaign for Research. All rights reserved.