EFFECTS OF CHLORPROMAZINE ON DECAY AND CONSOLIDATION OF SHORT-TERM MEMORY TRACES IN MICE

被引:16
作者
JOHNSON, FN
机构
[1] Department of Experimental Neuropharmacology, University of Birmingham, Birmingham
来源
PSYCHOPHARMACOLOGIA | 1969年 / 16卷 / 02期
关键词
Chlorpromazine; Memory Consolidation; Memory Decay; Passive Avoidance; Short-Term Memory;
D O I
10.1007/BF00403613
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
F1 hybrids of two highly inbred strains of mice were trained in a one-trial passive avoidance learning situation. Chlorpromazine, in doses of 0.5, 2.0 and 3.5 mg/kg, was administered at one of four injections times, 10 min before and 0.5, 2 and 10 min after learning. Pre-learning drug administration completely blocked acquisition of a learned avoidance response. Post-learning drug effects were more complex, involving reduced expression of avoidance learning but less rapid extinction of the learned response. The results were related to effects of the drug on short-term memory trace decay and consolidation. © 1969 Springer-Verlag.
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页码:105 / +
页数:1
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