DERIVATIVES OF SIDE-CHAIN HYDROXYLATED NITROSAMINES - DIRECT ACTING MUTAGENS IN SALMONELLA-TYPHIMURIUM

被引：29

作者：

MICHEJDA, CJ

ANDREWS, AW

KOEPKE, SR

机构：

[1] Carcinogenesis Program, NCI Frederick Cancer Research Center, Frederick

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 04期

关键词：

D O I：

10.1016/0165-1218(79)90025-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Methyl-(β-tosyloxyethyl)nitrosamine and 3-methyl-4,5-dihydro-1,2,3-oxadiazolium tosylate are potent direct acting mutagens in the Ames assay, as is N-nitrosoprolinyl tosylate. These compounds are derived from β-hydroxylated nitrosamines. The closely related methyl-(γ-tosyloxypropyl)nitrosamine is not mutagenic without activation. These data are consistent with the chemical behavior of these substances, which suggest that suitable derivatives of β-hydroxylated nitrosamines, such as O-sulfates, may be direct-acting biological alkylating agents. © 1979.

引用

页码：301 / 308

页数：8

共 17 条

[1] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].