ABNORMAL NEURULATION INDUCED BY 7-HYDROXY-2-ACETYLAMINOFLUORENE AND ACETAMINOPHEN - EVIDENCE FOR CATECHOL METABOLITES AS PROXIMATE DYSMORPHOGENS

被引:22
作者
HARRIS, C [1 ]
STARK, KL [1 ]
LUCHTEL, DL [1 ]
JUCHAU, MR [1 ]
机构
[1] UNIV WASHINGTON,SCH PUBL HLTH,DEPT ENVIRONM HLTH,SEATTLE,WA 98195
关键词
D O I
10.1016/0041-008X(89)90192-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:432 / 446
页数:15
相关论文
共 27 条
[1]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[2]   CHEMICAL TERATOGENESIS - TESTING METHODS AND THE ROLE OF METABOLISM [J].
BROWN, LP ;
FLINT, OP ;
ORTON, TC ;
GIBSON, GG .
DRUG METABOLISM REVIEWS, 1986, 17 (3-4) :221-260
[3]   NIRIDAZOLE METABOLISM BY RAT EMBRYOS INVITRO [J].
FANTEL, AG ;
PERSON, RE ;
TRACY, JW ;
JUCHAU, MR .
TERATOLOGY, 1988, 37 (03) :213-221
[4]  
FANTEL AG, 1979, LIFE SCI, V25, P425
[5]  
FAUSTMANWATTS E, 1983, TERATOLOGY, V27, P19, DOI 10.1002/tera.1420270105
[6]   TERATOGENICITY INVITRO OF 2 DEACETYLATED METABOLITES OF N-HYDROXY-2-ACETYLAMINOFLUORENE [J].
FAUSTMANWATTS, EM ;
GREENAWAY, JC ;
NAMKUNG, MJ ;
FANTEL, AG ;
JUCHAU, MR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 76 (01) :161-171
[7]   CARBON-MONOXIDE INHIBITS MONOOXYGENATION BY THE CONCEPTUS AND EMBRYOTOXIC EFFECTS OF PROTERATOGENS INVITRO [J].
FAUSTMANWATTS, EM ;
GIACHELLI, CM ;
JUCHAU, MR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1986, 83 (03) :590-595
[8]   ANALYSIS OF METABOLITES OF 2-ACETYLAMINOFLUORENE GENERATED IN AN EMBRYO CULTURE SYSTEM - RELATIONSHIP OF BIOTRANSFORMATION TO TERATOGENICITY INVITRO [J].
FAUSTMANWATTS, EM ;
NAMKUNG, MJ ;
GREENAWAY, JC ;
JUCHAU, MR .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (16) :2953-2959
[9]   MODULATION OF THE EMBRYOTOXICITY INVITRO OF REACTIVE METABOLITES OF 2-ACETYLAMINOFLUORENE BY REDUCED GLUTATHIONE AND ASCORBATE AND VIA SULFATION [J].
FAUSTMANWATTS, EM ;
NAMKUNG, MJ ;
JUCHAU, MR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1986, 86 (03) :400-410
[10]   DERIVATIVES OF FLUORENE .4. RANEY NICKEL-HYDRAZINE HYDRATE REDUCTION OF VARIOUS MONOFLUORENE AND DINITROFLUORENE DERIVATIVES - SOME NEW 9-SUBSTITUTED FLUORENES [J].
FLETCHER, TL ;
NAMKUNG, MJ .
JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (05) :680-683