INSITU BINDING OF BOUTON ZINC REVERSIBLY DISRUPTS PERFORMANCE ON A SPATIAL MEMORY TASK

被引：81

作者：

FREDERICKSON, RE

FREDERICKSON, CJ

DANSCHER, G

机构：

[1] UNIV TEXAS,NEUROBIOL LAB,BOX 688,RICHARDSON,TX 75080

[2] UNIV AARHUS,INST ANAT B,AARHUS C,DENMARK

来源：

BEHAVIOURAL BRAIN RESEARCH | 1990年 / 38卷 / 01期

关键词：

Chelation; Hippocampus; Memory; Rat; Spatial learning; Vesicle; Zinc;

D O I：

10.1016/0166-4328(90)90021-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neurons with zinc in the presynaptic vesicles innervate much of the telencephalon, but the functional significance of the vesicular zinc has never been established. The present work shows that reversible binding of zinc by drug infusion into the hippocampus produces a time-locked and selective disruption of hippocampal-dependent spatial-working memory. A role for vesicular zinc in neurotransmission or neuromodulation is implied. © 1990.

引用

页码：25 / 33

页数：9

共 39 条

[1] RELEASE OF ENDOGENOUS ZN-2+ FROM BRAIN-TISSUE DURING ACTIVITY [J].