VP-16, CYCLOPHOSPHAMIDE, ADRIAMYCIN AND CIS-PLATINUM (V-CAP-I) IN PATIENTS WITH METASTATIC ADENOCARCINOMA OF THE LUNG

In an attempt to improve upon the 42% regression rate of the CAP-I regimen in patients with advanced adenocarcinoma of the lung, VP-16 was added to that regimen. VP-16, as a single agent, had a response rate of 12.5% (3/24) in a similar group of patients. The new regimen, V:CAP-I, had a tumor regression rate of 35% (7/20) and an estimated median survival of 171 days. Hence, the authors were unable to conclude that the addition of VP-16 to the CAP-I regimen statistically improved the regression rate of the CAP-I regimen.