MODIFICATION OF POSTSYNAPTIC DOPAMINERGIC SENSITIVITY BY FEMALE SEX-HORMONES

被引：116

作者：

NAUSIEDA, PA

KOLLER, WC

WEINER, WJ

KLAWANS, HL

机构：

[1] Dept. of Neurological Sciences Rush-Presbyterian-St. Luke's Medical Center 1725 West Harrison Chicag

来源：

LIFE SCIENCES | 1979年 / 25卷 / 06期

关键词：

D O I：

10.1016/0024-3205(79)90564-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stereotyped behavior in response to d-amphetamine or apomorphine was significantly reduced in female guinea pigs following cophorectamy. Responsiveness to either dopamine agonist was significantly increased by the subsequent chronic administration of either estradiol valerate or progesterone. Modification of postsynatpic dopaminergic sensitivity by female sex hormones may underly the clinical association of hyperkinetic movement disorders, psychosis or depression seen with alterations in female sex hormones in man. © 1979.

引用

页码：521 / 526

页数：6

共 16 条

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