1991 VOLVO AWARD IN CLINICAL SCIENCES - SMOKING AND LUMBAR INTERVERTEBRAL-DISK DEGENERATION - AN MRI STUDY OF IDENTICAL-TWINS

被引：278

作者：

BATTIE, MC

VIDEMAN, T

GILL, K

MONETA, GB

NYMAN, R

KAPRIO, J

KOSKENVUO, M

机构：

[1] Department of Orthopaedics, University of Washington, Seattle, WA

[2] Department of Health Sciences, University of Jyvaskyla, Jyvaskyla

[3] Department of Orthopaedics, University of Texas Southwestern Medical Center, Dallas, TX

[4] Department of Epidemiology and Biostatistics, Institute of Occupational Health, Helsinki

[5] Dcpartment of Radiology, University Hospital, Uppsala

[6] Department of Public Health, University of Helsinki, Helsinki

[7] Department of Public Health, University of Turku, Turku

来源：

SPINE | 1991年 / 16卷 / 09期

关键词：

SMOKING; DISK DEGENERATION; MAGNETIC RESONANCE IMAGING; LOW-BACK PAIN; IDENTICAL TWINS;

D O I：

10.1097/00007632-199109000-00001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The primary objective of this study was to determine whether disc degeneration, as assessed through magnetic resonance imaging, is greater in smokers than in nonsmokers. To control for the maximum number of potentially confounding variables, pairs of identical twins highly discordant for cigarette smoking were selected as study subjects. Data analyses revealed 18% greater mean disc degeneration scores in the lumbar spines of smokers as compared with nonsmokers. The effect was present across the entire lumbar spine, implicating a mechanism acting systemically. This investigation demonstrates the efficiency of using carefully selected controls in studying conditions of multifactorial etiology, such as disc degeneration.

引用

页码：1015 / 1020

页数：6

共 46 条

[1]

American Cancer Society: Facts and Figures on Smoking, (1976)

[2]

Battie M.C., Bigos S.J., Fisher L.D., Et al., A prospective study of the role of cardiovascular risk factors and fitness in industrial back pain complaints, Spine, 14, pp. 141-147, (1989)

[3]

Biering-S0rensen F., Thomsen C., Medical, social and occupational history as risk indicators for low-back trouble in a general population, Spine, 11, pp. 720-725, (1986)

[4]

Biering-S0rensen F., Thomsen C.E., Hilden J., Risk indicators for low back trouble, Scand J Rehabil Med, 21, pp. 151-157, (1989)

[5]

Brown C.W., Orme T.J., Richardson H.D., The rate of pseudarthrosis (Surgical nonunion) in patients who are smokers and patients who are nonsmokers: A comparison study, Spine, 11, pp. 942-943, (1986)

[6]

Burton A.K., Regional lumbar sagittal mobility: Measurement by flexicurves, Clin Biomech, 20, 1, pp. 20-26, (1986)

[7]

Cox J.M., Trier K.K., Exercise and smoking habits in patients with and without low back and leg pain, J Manipulative Physiol Ther, 10, pp. 239-245, (1987)

[8]

Craven T.E., Ryu J.E., Espeland M.A., Et al., Evaluation of the associations between carotid artery arteriosclerosis and coronary artery stenosis: A casc-control study, Circulation, 82, 4, pp. 1230-1242, (1990)

[9]

Danieli H.W., Osteoporosis of the slender smoker: Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity, Arch Intern Med, 136, pp. 298-304, (1976)

[10]

Dewey M.E., Dickinson C.E., Foreman T.K., Troup J., Back pain, ventila¬tory function, chest symptoms, and smoking, J Spinal Disord, 2, pp. 241-248, (1989)

← 1 2 3 4 5 →