THE RELATIONSHIP OF CEREBROSPINAL-FLUID MONOAMINE METABOLITES WITH CLINICAL-RESPONSE TO TETRAHYDROAMINOACRIDINE IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：25

作者：

ALHAINEN, K

HELKALA, EL

REINIKAINEN, K

RIEKKINEN, P

机构：

[1] Department of Neurology, University of Kuopio, Kuopio, SF-70211

来源：

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION | 1993年 / 5卷 / 03期

关键词：

ALZHEIMERS DISEASE; THA; CEREBROSPINAL FLUID; MONOAMINE METABOLITES; COGNITIVE TESTS; ATTENTION; ACTIVITIES OF DAILY LIVING;

D O I：

10.1007/BF02257673

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of tetrahydroaminoacridine (THA) on the cerebrospinal fluid (CSF) monoamine metabolites was studied in 22 patients with Alzheimer's disease in an open treatment trial. The CSF monoamine metabolites were assayed at baseline and after 4 weeks' active THA treatment with 100 mg/d. A statistically significant increase in the CSF homovanillic acid (HVA) and in 5-hydroxyindoleacetic acid (5-HIAA) content was found. The increase of the CSF 5-HIAA level correlated significantly with improvement in cognitive tests and in the Instrumental Activities of Daily Living Scale. We conclude that besides its anticholinesterase activity THA enhances also the monoaminergic neurotransmission in the brain and that the clinical improvement during THA treatment may be partly mediated through the monoaminergic system.

引用

页码：185 / 192

页数：8

共 29 条

[1] TETRAHYDROAMINOACRIDINE INHIBITS HUMAN AND RAT-BRAIN MONOAMINE-OXIDASE [J].