INDUCTION OF APOPTOSIS IN MURINE ACTH-SECRETING PITUITARY-ADENOMA CELLS BY BROMOCRIPTINE

被引:56
作者
YIN, DL [1 ]
KONDO, S [1 ]
TAKEUCHI, J [1 ]
MORIMURA, T [1 ]
机构
[1] NATL UTANO HOSP,DEPT NEUROSURG,UKYO KU,KYOTO,KYOTO 616,JAPAN
关键词
APOPTOSIS; PITUITARY TUMOR; BROMOCRIPTINE;
D O I
10.1016/0014-5793(94)80387-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bromocriptine, a dopamine agonist, is now an accepted primary therapeutic agent for patients with prolactinomas and other pituitary adenomas. In this study, we demonstrated that bromocriptine inhibited the proliferation of murine ACTH-secreting pituitary adenoma (AtT-20) cells. In addition, the antitumor activity of bromocriptine was inhibited both by actinomycin D and cycloheximide, suggesting that it was dependent on new RNA and protein synthesis. Interestingly, the results of DNA fragmentation assays and cell cycle analysis clearly demonstrated that bromocriptine induced apoptosis in AtT-20 cells.
引用
收藏
页码:73 / 75
页数:3
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