SYNTHESIS AND COMPLEMENTARY COMPLEX-FORMATION PROPERTIES OF OLIGONUCLEOTIDES COVALENTLY-LINKED TO NEW STABILIZING AGENTS

被引：21

作者：

BALBI, A ^{[1
]}

SOTTOFATTORI, E ^{[1
]}

GRANDI, T ^{[1
]}

MAZZEI, M ^{[1
]}

ABRAMOVA, TV ^{[1
]}

LOKHOV, SG ^{[1
]}

LEBEDEV, AV ^{[1
]}

机构：

[1] INST BIOORGAN CHEM,NOVOSIBIRSK,RUSSIA

来源：

TETRAHEDRON | 1994年 / 50卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(01)89676-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligodeoxyribonucleotides of different lengths have been prepared and linked to new stabilizing agents related to the coumarin family. These ODNSAs (OligoDeoxyriboNucleotides with Stabilizing Agents) were tested against acridine connected oligomers of the same sequence. Melting temperature experiments demonstrated that all ODNSAs formed complexes of increased stability with complementary sequences of deoxyribo-20-mer. The order of stability of duplexes showed that the coumarins stabilize the complexes more than the acridine and the chromone derivatives.

引用

页码：4009 / 4018

页数：10

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