EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I GENE IN OSMOREGULATORY ORGANS DURING SEAWATER ADAPTATION OF THE SALMONID FISH - POSSIBLE MODE OF OSMOREGULATORY ACTION OF GROWTH-HORMONE

被引:157
作者
SAKAMOTO, T
HIRANO, T
机构
[1] Ocean Research Institute, University of Tokyo, Nakano
[2] Ocean Research Institute, University of Tokyo, Nakano-ku, Tokyo 164, 1-15-1, Minamidai
关键词
GENE REGULATION; RNA HYBRIDIZATION; GILL; KIDNEY; RAINBOW TROUT;
D O I
10.1073/pnas.90.5.1912
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Growth hormone has been shown to contribute to seawater adaptation of salmonid fishes. The growth influence of growth hormone is mediated largely by hepatic production of insulin-like growth factor I (IGF-I). To study the growth hormone-IGF-I axis in osmoregulation, we measured IGF-I mRNA in the liver, gill, and body kidney from rainbow trout by Northern analysis. The levels of IGF-I mRNA in all tissues increased significantly after injection of growth hormone. Transfer of trout from fresh water to 80% seawater evoked an increase in plasma growth hormone after 1 day. IGF-I mRNA was not altered significantly in the liver, but it was increased in the gill and body kidney after 1 and 8 days, respectively. These observations indicate that the IGF-I gene is expressed differently among these organs during seawater adaptation. Growth hormone may stimulate hypoosmoregulatory ability by inducing local expression of IGF-I in osmoregulatory organs, although the possibility that IGF-I expression might occur in part independently of growth hormone during seawater adaptation cannot be excluded.
引用
收藏
页码:1912 / 1916
页数:5
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