GLUTATHIONE METABOLISM IN CROHNS-DISEASE

被引：47

作者：

IANTOMASI, T ^{[1
]}

MARRACCINI, P ^{[1
]}

FAVILLI, F ^{[1
]}

VINCENZINI, MT ^{[1
]}

FERRETTI, P ^{[1
]}

TONELLI, F ^{[1
]}

机构：

[1] UNIV FLORENCE,IST PATOL CHIRURG,I-50134 FLORENCE,ITALY

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1994年 / 53卷 / 02期

关键词：

D O I：

10.1006/bmmb.1994.1062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A statistically significant decrease of glutathione (GSH) and an increase of GSH disulfide (GSSG) both in healthy and ill ileum of patients with Crohn's disease in comparison with the controls (without this pathology) is demonstrated. However, the lowering of these levels was more remarkable in ill ileum in which high levels of GSSG were detected, too. These alterations may be in part explained by the changes obtained in GSH-related enzyme levels. Finally, considering the results that others and we obtained by studies on GSH oral absorption in rat intestine, an oral therapy of GSH in Crohn's disease is suggested. (C) 1994 Academic Press, Inc.

引用

页码：87 / 91

页数：5

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