PREDICTION OF DRUG-RELEASE FROM HYDROXYPROPYL METHYLCELLULOSE (HPMC) MATRICES - EFFECT OF POLYMER CONCENTRATION

被引：59

作者：

SHAH, N

ZHANG, GH

APELIAN, V

ZENG, FW

INFELD, MH

MALICK, AW

机构：

[1] HOFFMANN LA ROCHE INC,PHARMACEUT RES & DEV,NUTLEY,NJ 07110

[2] QIAOGUANG PHARMACEUT,PROC DEV,GUANGDONG,PEOPLES R CHINA

来源：

PHARMACEUTICAL RESEARCH | 1993年 / 10卷 / 11期

关键词：

HYDROXYPROPYL METHYLCELLULOSE; DRUG RELEASE MECHANISM; PREDICTION OF DRUG RELEASE; OPTIMIZATION OF DRUG RELEASE; HYDROGEL DELIVERY SYSTEM;

D O I：

10.1023/A:1018901509855

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1693 / 1695

页数：3

共 8 条

[1]

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[2] IMPORTANCE OF DRUG TYPE, TABLET SHAPE AND ADDED DILUENTS ON DRUG RELEASE KINETICS FROM HYDROXYPROPYLMETHYLCELLULOSE MATRIX TABLETS [J].

FORD, JL ;

RUBINSTEIN, MH ;

MCCAUL, F ;

HOGAN, JE ;

EDGAR, PJ .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 40 (03) :223-234

[3]

GRAHAM NB, 1984, BIOMATERIALS, V5, P27, DOI 10.1016/0142-9612(84)90063-2

[4] MECHANISMS OF SOLUTE RELEASE FROM POROUS HYDROPHILIC POLYMERS [J].

KORSMEYER, RW ;

GURNY, R ;

DOELKER, E ;

BURI, P ;

PEPPAS, NA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1983, 15 (01) :25-35

[5]

LEE PI, 1986, ADV DRUG DELIVERY SY, P277

[6]

Pedley D.G., 1980, BRIT POLYM J, V12, P99, DOI [10.1002/PI.4980120306, DOI 10.1002/PI.4980120306]

[7]

PEPPAS NA, 1985, PHARM ACTA HELV, V60, P110

[8]

ZHANG XY, 1990, THESIS PHILADELPHIA

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