A NOVEL-APPROACH TO THE MICRODOSIMETRY OF NEUTRON-CAPTURE THERAPY .1. HIGH-RESOLUTION QUANTITATIVE AUTORADIOGRAPHY APPLIED TO MICRODOSIMETRY IN NEUTRON-CAPTURE THERAPY

被引：49

作者：

SOLARES, GR

ZAMENHOF, RG

机构：

[1] TUFTS UNIV,SCH MED,BOSTON,MA 02111

[2] TUFTS UNIV NEW ENGLAND MED CTR,BOSTON,MA 02111

来源：

RADIATION RESEARCH | 1995年 / 144卷 / 01期

关键词：

D O I：

10.2307/3579235

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A novel approach to the microdosimetry of neutron capture therapy has been developed using high-resolution quantitative autoradiography (HRQAR) and two-dimensional Monte Carlo simulation. This approach has been applied using actual cell morphology (nuclear and cytoplasmic cell structures) and the measured microdistribution of boron-10 in a transplanted murine brain tumor (GL261) containing p-boronophenylalanine (BPA) as the boron compound. The 2D Monte Carlo transport code for the alpha and Li-7 charged particles from the B-10(n,alpha)Li-7 reactions has been developed as a surrogate to a full 3D approach to calculate a variety of different microdosimetric parameters. The HRQAR method and the surrogate 2D Monte Carlo approach are described in detail and examples of their use are presented. (C) 1995 by Radiation Research Society

引用

页码：50 / 58

页数：9

共 27 条

[1]

Andrews H, 1977, DIGITAL IMAGE RESTOR

[2]

CARPENTER BS, 1972, MICROSCOPE, V20, P175

[3] ENERGY DEPOSITION IN SMALL ELLIPSOIDAL VOLUMES BY HIGH-LET PARTICLES - APPLICATION TO THERMAL-NEUTRON DOSIMETRY [J].