PERHEXILINE INDUCES GENERALIZED LIPIDOSIS IN RATS

被引：26

作者：

LULLMANN, H ^{[1
]}

LULLMANNRAUCH, R ^{[1
]}

机构：

[1] UNIV KIEL,DEPT ANAT,D-2300 KIEL 1,FED REP GER

来源：

KLINISCHE WOCHENSCHRIFT | 1978年 / 56卷 / 06期

关键词：

Generalized lipidosis; Perhexiline maleate; Rat;

D O I：

10.1007/BF01489178

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Administration of perhexiline (Pexide®) to rats causes generalized occurrence of lamellated and crystalloid cytoplasmic inclusions which resemble those described in patients with perhexiline-induced polyneuropathy. It is concluded that perhexiline being an amphiphilic cationic compound is a potent inducer of generalized lipidosis. © 1978 Springer-Verlag.

引用

页码：309 / 310

页数：2

共 7 条

[1]

LAGERON A, 1977, LANCET, V1, P483

[2]

LHERMITTE F, 1976, BRIT MED J, V2, P1265

[3]

Lullmann H, 1975, CRC Crit Rev Toxicol, V4, P185

[4]

LULLMANN H, 1973, DEUT MED WOCHENSCHR, V98, P1616

[5] CHLORPHENTERMINE-INDUCED ABNORMAL CYTOPLASMIC INCLUSIONS IN PERIPHERAL-BLOOD CELLS OF RATS AND GUINEA-PIGS [J].

LULLMANNRAUCH, R .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1975, 32 (01) :32-39

[6]

LULLMANNRAUCH R, 1975, VIRCHOWS ARCH B, V19, P255

[7]

MUSSINI JM, 1977, ACTA NEUROPATHOL, V38, P53, DOI 10.1007/BF00691277

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