SEQUENTIAL PARTICIPATION OF GLUTATHIONE AND SULF-HYDRYL (S) IN REDUCTIVE DECHLORINATION OF 2,4-DICHLORO, AND 2,4,5-TRICHLORO PHENACYL CHLORIDES BY SOLUBLE FRACTION (105,000XG) OF CHICKEN LIVER HOMOGENATE

The mode of reductive dechlorination of a-chloroacetophenones, 2,4-di-, and 2,4,5-trichloro phenacyl chlorides into respective acetophenone by soluble fraction (105,000 x g) from chicken liver homogenate has been investigated. The transformation involved the sequential participation of glutathione and a sulph-hydryl. The phenacyl chloride first reacted with glutathione to yield the phenacyl glutathione, which in turn, in the presence of a sulph-hydryl, was reduced enzymatically to produce the ketone, probably via a disulfide intermediate. Copyright © 1979 by Marcel Dekker, Inc. All Rights Reserved.