GENETIC INDEPENDENCE OF THE EMBRYONIC REACTIVITY DIFFERENCE TO CORTISONE-INDUCED AND 6-AMINONICOTINAMIDE-INDUCED CLEFT-PALATE IN THE MOUSE

被引：7

作者：

BIDDLE, FG

FRASER, FC

机构：

[1] Department of Biology, McGill University, Montreal, Quebec, H3A 1B1

[2] Faculty of Medicine — Basic Sciences, Memorial University of Newfoundland, St. John'S, Newfoundland

来源：

TERATOLOGY | 1979年 / 19卷 / 02期

关键词：

D O I：

10.1002/tera.1420190211

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The A/J strain of mice is more reactive than C57BL/6J to both cortisone‐ and 6‐aminonicotinamide‐induced cleft palate. A breeding study was set up to determine the genetic control of the differences in embryonic reactivity between the two strains to the two teratogens. In this paper the test for possible association between the two response traits is presented. In the second‐backcross generation of embryos where segregation of the two traits could be studied no association was found. Therefore, any embryonic genes making major contributions to differences in reactivity between the two strains are not the same for the two teratogens. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：207 / 212

页数：6

共 20 条

[1]

BIDDLE FG, 1977, GENETICS, V85, P289

[2] USE OF DOSE-RESPONSE RELATIONSHIPS TO DISCRIMINATE BETWEEN MECHANISMS OF CLEFT-PALATE INDUCTION BY DIFFERENT TERATOGENS - ARGUMENT FOR DISCUSSION [J].