25-HYDROXYCHOLECALCIFEROL - STIMULATION OF BONE RESORPTION IN TISSUE CULTURE

被引：156

作者：

TRUMMEL, CL

RAISZ, IG

BLUNT, JW

DELUCA, HF

机构：

[1] Departments of Dentistry and Dental Research and Pharmacology, School of Medicine and Dentistry, University of Rochester, Rochester

来源：

SCIENCE | 1969年 / 163卷 / 3874期

关键词：

D O I：

10.1126/science.163.3874.1450

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

25-Hydroxycholecalciferol stimulates release of previously incorporated calcium-45 from fetal rat bones in doses of 0.9 to 27 units per milliliter. This effect cannot be produced by much larger doses of vitamin D3. Comparison of stimulation of bone resorption by 25-hydroxycholecalciferol and parathyroid hormone reveals similarities with respect to time course, dose-response slope, and inhibition by calcitonin.

引用

页码：1450 / &

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