HEMOLYTIC PROPERTIES OF EXTRACTS OF TENTACLES FROM CNIDARIAN CHIRONEX FLECKERI

被引:44
作者
KEEN, TEB
CRONE, HD
机构
[1] Australian Defence Scientific Service, Defence Standards Laboratories, Melbourne, Vic.
基金
英国医学研究理事会;
关键词
D O I
10.1016/0041-0101(69)90164-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The properties of an extract of the tentacles from Chironex fleckeri were examined to determine the nature of the hemolysin. The hemolysin was labile at room temperatures but when care was taken to prevent deterioration it had a high degree of activity which was unaffected by cholesterol. There was a non-linear relation between the rate of hemolysis and the dilution of the extract and this rate was dependent on temperature and pH. The activity of the hemolysin was inhibited by sucrose and plasma and accelerated by benzene. There was a correlation between the hemolysin titre and the ld50 of a series of crude extracts. © 1969.
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页码:55 / &
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