AGE-RELATED-CHANGES IN CEREBROSPINAL-FLUID PROTEIN CONCENTRATIONS

被引:89
作者
GARTON, MJ
KEIR, G
LAKSHMI, MV
THOMPSON, EJ
机构
[1] HOPE HOSP, DEPT GERIATR MED, SALFORD M6 8HD, LANCS, ENGLAND
[2] UCL NATL HOSP NEUROL & NEUROSURG, JOHN N CUMINGS LAB, LONDON WC1N 3BG, ENGLAND
关键词
AGING; ALBUMIN; BLOOD BRAIN BARRIER; IGG; PREALBUMIN; ALPHA-2-MACROGLOBULIN; PROTEINS; CHOROID-PLEXUS EPITHELIUM; REFERENCE VALUES; TIGHT JUNCTIONS; IGG; CSF; BARRIER; BRAIN; ESTABLISHMENT; TRANSPORT; ALBUMIN;
D O I
10.1016/0022-510X(91)90218-V
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The blood-brain barrier (BBB) has a key role in CSF homeostasis and preservation of normal neuronal function. There has been little investigation of changes in barrier function in elderly subjects without evidence of neurological disease. The ageing brain demonstrates increased vulnerability to a variety of insults, which may reflect a deterioration in barrier performance. Direct measurement of BBB function is difficult but the CSF/serum quotients of individual proteins is the most widely used parameter. The present study sought age related changes in the CSF/serum quotients of prealbumin, albumin, immunoglobulin G and alpha-2-macroglobulin in adults with no neurological deficit. A prospective study was established, and 107 subjects (aged 18-89 yrs) were recruited from patients undergoing spinal anaesthesia or diagnostic myelography. A weak but significant positive correlation was found between the CSF/serum quotients and age for all the proteins studied, but with the exception of alpha-2-macroglobulin, these changes probably reflect age related falls in serum protein concentrations found in this study. Alpha-2-Macroglobulin appears to be a sensitive indicator of barrier function for large populations. suggesting a subtle decline of BBB integrity with increasing age. This may be a true age-related change or could reflect an increased incidence of subclinical disease in an ageing population.
引用
收藏
页码:74 / 80
页数:7
相关论文
共 20 条
[1]   TRANSFER OF ALBUMIN-I-125 FROM BLOOD INTO BRAIN AND CEREBROSPINAL-FLUID IN NEWBORN AND JUVENILE RATS [J].
AMTORP, O .
ACTA PHYSIOLOGICA SCANDINAVICA, 1976, 96 (03) :399-406
[2]   BLOOD-BRAIN BARRIER TO PROTEINS UNDER NORMAL AND PATHOLOGICAL CONDITIONS [J].
BRIGHTMA.MW ;
KLATZO, I ;
OLSSON, Y ;
REESE, TS .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1970, 10 (03) :215-&
[3]   AGAR-GEL MICRO-ELECTROPHORESIS OF PROTEINS IN CEREBROSPINAL FLUID NORMAL + PATHOLOGICAL FINDINGS [J].
CLAUSEN, J ;
GERHARDT, W ;
MATZKE, J .
ACTA NEUROLOGICA SCANDINAVICA, 1964, 40 :49-&
[4]   PROTEIN SIZE AND CEREBROSPINAL-FLUID COMPOSITION [J].
FELGENHAUER, K .
KLINISCHE WOCHENSCHRIFT, 1974, 52 (24) :1158-1164
[5]  
FREMONT-SMITH FRANK, 1931, ARCH NEUROL AND PSYCH, V25, P1271
[6]  
GANROT K, 1974, CLIN CHEM, V20, P571
[7]  
Goldmann EE., 1909, BEITR KLIN CHIR, V64, P192
[8]   TRANSTHYRETIN - A CHOROID PLEXUS-SPECIFIC TRANSPORT PROTEIN IN HUMAN-BRAIN [J].
HERBERT, J ;
WILCOX, JN ;
PHAM, KTC ;
FREMEAU, RT ;
ZEVIANI, M ;
DWORK, A ;
SOPRANO, DR ;
MAKOVER, A ;
GOODMAN, DS ;
ZIMMERMAN, EA ;
ROBERTS, JL ;
SCHON, EA .
NEUROLOGY, 1986, 36 (07) :900-911
[9]   PROTEINS AS PARAMETERS IN THE DISCRIMINATION BETWEEN DIFFERENT BLOOD CSF BARRIERS [J].
KEIR, G ;
THOMPSON, EJ .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1986, 75 (03) :245-253
[10]   CORRELATION BETWEEN PROTEIN DATA IN NORMAL LUMBAR CSF AND MORPHOLOGICAL FINDINGS OF CHOROID-PLEXUS EPITHELIUM - A BIOCHEMICAL CORROBORATION OF BARRIER TRANSPORT VIA TIGHT JUNCTION PORES [J].
KLUGE, H ;
HARTMANN, W ;
MERTINS, B ;
WIECZOREK, V .
JOURNAL OF NEUROLOGY, 1986, 233 (04) :195-199