PROSTACYCLIN STIMULATES THE RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM IN MAN

被引：34

作者：

MIYAMORI, I ^{[1
]}

FITZGERALD, GA ^{[1
]}

BROWN, MJ ^{[1
]}

LEWIS, PJ ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT CLIN PHARMACOL, LONDON W12 0HS, ENGLAND

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 49卷 / 06期

关键词：

D O I：

10.1210/jcem-49-6-943

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of prostacyclin (PGI2) on the renin-angiotensin-aldosterone system (RAA) has been examined in 6 normal male volunteers infused with 3 incremental doses of PGI2. Diastolic blood pressure fell significantly during the infusion of the highest dose of 8 ng/kg/min. Plasma renin activity (PRA) and plasma angiotensin II (All) increased to 271% and 3425 respectively from baseline values. Plasma cortisol (PC), plasma noradrenaline (PNA) and plasma adrenaline (PAD) did not change significantly. Plasma aldosterone (PA) increased slightly 15 minutes after stopping the infusion. These results suggest that PGI2 stimulates the release of renin in man. © 1979 by The Endocrine Society.

引用

页码：943 / 944

页数：2

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