SESQUITERPENE LACTONES - TOTAL SYNTHESIS OF (+/-)-VERNOLEPIN

被引：28

作者：

ZUTTERMAN, F ^{[1
]}

DEWILDE, H ^{[1
]}

MIJNGHEER, R ^{[1
]}

DECLERCQ, P ^{[1
]}

VANDEWALLE, M ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,ORGAN SYNTH LAB,B-9000 GHENT,BELGIUM

来源：

TETRAHEDRON | 1979年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4020(01)93755-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthesis of (± )-Vernolepin (1) is described. A suitably substituted cis-fused 2-oxa-3-decalone precursor (29) has been constructed starting from 2,5-cyclohexadiene carboxylic acid via an intramolecular cyclopropanation reaction (23 to 18). The route culminated in the synthesis of Grieco's lactone (53) which has previously been converted to (± )-vernolepin (1) and (± )-vernomenin (2). © 1979.

引用

页码：2389 / 2396

页数：8

共 32 条

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